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The structural formula is represented below: Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. Pharmacists can take an active role in preventing counterfeit drugs by ensuring that they source products only from a reputable wholesaler or distributor. WebXanax Pfizer 2mg. Thanks, Your email address will not be published. BioNTech and Pfizer have advance purchase agreements of about US$3billion to provide a licensed vaccine in the United States, the European Union, the United Kingdom, Japan, Canada, Peru, Singapore and Mexico. 2 mg tablets) may be priced higher. Order now. The name of the company commemorates its co-founder, Charles Pfizer (1824-1906). Pfizer is recalling thousands of bottles of its anxiety drug Xanax, saying the drug may not be strong enough. It may also be used for other conditions as determined by your doctor. Xanax alprazolam tablets, USP. Other common Xanax side effects include: Difficulty speaking Problems with coordination Most patients showed a response in the dosage range of 3 mg to 6 mg per day. It is authorized for use at some level in 84 countries including the United States and Canada, countries in the European Union, the United Kingdom, Australia, Ukraine, Israel, Brazil, Bangladesh, Mexico, Japan and Singapore. Table 2 shows the incidence of adverse reactions that occurred during 6- and 8-week placebo-controlled trials in 1% or more of patients treated with XANAX XR where the incidence in patients treated with XANAX XR was greater than the incidence in placebo-treated patients. Though Xanax does have legitimate medical uses, some people abuse it or take it recreationally. WebXANAX (alprazolam) This product information is intended only for residents of the United States. Following is a list of other adverse reaction reported by 531 patients with panic disorder treated with XANAX XR. Paradoxical reactions such as stimulation, increased muscle spasticity, sleep disturbances, hallucinations, and other adverse behavioral effects such as agitation, rage, irritability, and aggressive or hostile behavior have been reported rarely. In some cases, they may not be available in every strength or form as the brand-name version. The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. It is not necessary to reduce XANAX XR dosage in patients who have been taking ritonavir for more than 10 to 14 days. Vaccination requires two doses given three weeks apart. Short term administration of ritonavir increased alprazolam exposure due to CYP3A4 inhibition. If you take too much XANAX XR, call your healthcare provider or go to the nearest hospital emergency room right away. Each segment is meant to be a single 0.5 mg dose of Xanax. Lactation: Breastfeeding not recommended. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of the following symptoms. I never even stated that the pills are real pharmaceutical grade. Alprazolam is 80% bound to human serum protein, and albumin accounts for the majority of the binding. Both types of white Xanax pills are manufactured by Pfizer. Adverse Reactions Occurring at an Incidence of 1% or More Among Patients Treated with XANAX XR. Pill with imprint XANAX 2 is White Long Bar, Anxiety Disorders. Preston Mcelheney Drug abuse and dependence: Even when used as recommended, alprazolam may cause emotional or physical dependence (addiction). (, Use with CYP3A Inducers: Increase the risk of reduced efficacy of alprazolam. Highly recommend Pharmacy. (8.2). These include a spectrum of withdrawal symptoms; the most important is seizure [see Drug Abuse and Dependence (9.3)]. See 17 for PATIENT COUNSELING INFORMATION and Medication Guide. Though Xanax does have legitimate medical uses, some people abuse it or take it recreationally. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. This product's labeling may have been updated. Before prescribing XANAX and throughout treatment, assess each patients risk for abuse, misuse, and addiction. Michael Langley To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage [see Dosage and Administration (2.3), Warnings and Precautions (5.3)]. In the U.S. general population, the estimated risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. These highlights do not include all the information needed to use XANAX XR safely and effectively. Some patients may benefit from an even more gradual discontinuation. Physician Prescribing Information and Patient Information on this page may no longer be current. In order to properly inform the public, we have developed the following statement to be placed at the top of certain product pages: The products on this page have been transferred to VIATRIS SPECIALTY LLC. a history of drug or alcohol addiction; or The pharmacokinetic parameters at steady-state for the two hydroxylated metabolites of alprazolam (4-hydroxyalprazolam and -hydroxyalprazolam) were similar for XANAX and XANAX XR, indicating that the metabolism of alprazolam is not affected by absorption rate. the price margin is also affordable and the best part about usamedzone services are their customer support. If an opioid is initiated in a patient already taking XANAX XR, prescribe a lower initial dose of the opioid and titrate based upon clinical response. I never even stated that the pills are real pharmaceutical grade. Fluoxetine: Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased T1/2 by 17%, and decreased measured psychomotor performance. I already purchased product many times form usamedzone shop and my experience was fantastic. XANAX XR contains alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. Xanax is a powerful Benzodiazepine that is often prescribed to treat generalized anxiety disorder (GAD), panic disorders, and insomnia. The initial step in alprazolam metabolism is hydroxylation catalyzed by cytochrome P450 3A (CYP3A). Easy to order and reorder. The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Advise both patients and caregivers about the risks of potentially fatal respiratory depression and sedation when XANAX XR is used with opioids and not to use such drugs concomitantly unless supervised by a healthcare provider. -Slurred speech Maximal concentrations and T1/2 of alprazolam are approximately 15% and 25% higher in Asians compared to Caucasians. A person who uses alprazolam regularly and has built up a tolerance to it, might feel euphoric or extremely mellow, but someone who is not used to the drug may become heavily sedated. An immediate-release drug is released into the bloodstream more quickly. Physical dependence is not the same as drug addiction. Important warnings Isolated published reports involving small numbers of patients have suggested that patients who have borderline personality disorder, a prior history of violent or aggressive behavior, or alcohol or substance abuse may be at risk for such events. Further increase in the dose (up to 0.5-0.75 mg / day) is carried out with caution for good tolerability of the drug. The ability of alprazolam to induce human hepatic enzyme systems has not yet been determined. You should not get the second dose early. You and your healthcare provider should decide if you should take XANAX XR while you are pregnant. The products discussed herein may have different labeling in different countries. It is dangerous to purchase Xanax on the Internet or outside the United States. ( 1) DOSAGE AND ADMINISTRATION Recommended starting oral dosage is 0.5 mg to 1 mg once daily (preferably in the morning). CIV. It is not known if XANAX XR is safe and effective in children. Geriatric patients may be sensitive to the effects of benzodiazepines [see Use in Specific Populations (8.5), Clinical Pharmacology (12.3)]. Elderly and weakened patients 0.25 mg 2-3 times a day. The pharmacokinetics of alprazolam and two of its major active metabolites (4-hydroxyalprazolam and -hydroxyalprazolam) are linear, and concentrations are proportional up to 10 mg XANAX XR given once daily. Adverse Reactions Observed in Short-Term, Placebo-Controlled Trials of XANAX XR, Adverse Reactions Reported as Reasons for Discontinuation of Treatment in Placebo-Controlled Trials. For its development BioNTech collaborated with Pfizer, an American company, for support with clinical trials, logistics, and manufacturing. Limit dosages and durations to the minimum required. white, pentagonal shaped tablets debossed with an "X" on one side and "0.5" on the other side, yellow, square shaped tablets debossed with an "X" on one side and "1" on the other side, blue, round shaped tablets debossed with an "X" on one side and "2" on the other side, green, triangular shaped tablets debossed with an "X" on one side and "3" on the other side. XANAX XR is a federal controlled substance (C-IV) because it contains alprazolam that can be abused or lead to dependence. Take XANAX XR exactly as your healthcare provider tells you to take it. Protracted withdrawal syndrome associated with benzodiazepines is characterized by anxiety, cognitive impairment, depression, insomnia, formication, motor symptoms (e.g., weakness, tremor, muscle twitches), paresthesia, and tinnitus that persists beyond 4 to 6 weeks after initial benzodiazepine withdrawal. Reduce the digoxin dose if necessary. Xanax side effects However, in a controlled postmarketing discontinuation study of panic disorder patients who received XANAX, the duration of treatment (3 months compared to 6 months) had no effect on the ability of patients to taper to zero dose. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Required fields are marked *. WebXANAX XR is a benzodiazepine indicated for the treatment of panic disorder with or without agoraphobia, in adults. XANAX XR U.S. Abuse and misuse of benzodiazepines may lead to addiction. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage (a patient-specific plan should be used to taper the dose) [see Dosage and Administration (2.3)]. Because of the potential for serious adverse reactions, including sedation and withdrawal symptoms in breastfed neonates and infants, advise patients that breastfeeding is not recommended during treatment with XANAX XR. WebWomen's Health. XANAX XR can make you sleepy or dizzy and can slow your thinking and motor skills. (6.1). XANAX XR is contraindicated with concomitant use of all strong CYP3A inhibitors, except ritonavir [see Contraindications (4), Warnings and Precautions (5.5), Drug Interactions (7.1)]. Do not drive, operate heavy machinery, or do other dangerous activities until you know how XANAX XR affects you. Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted. Spontaneous reporting system data suggest that the risk of dependence and its severity appear to be greater in patients treated with doses greater than 4 mg/day and for long periods (more than 12 weeks). Depending upon the response, the dosage may be adjusted at intervals of every 3 to 4 days. WebA white Xanax bar contains 2 mg in one whole pill, but can easily be split into four different segments. 1 line going down the center of the 2. This may be gradually increased if needed and tolerated. Xanax is used to treat anxiety disorders and anxiety caused by depression. Instruct patients that discontinuation or dosage reduction of XANAX XR may require a slow taper [see Warnings and Precautions (5.3), Drug Abuse and Dependence (9.3)]. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage. It is dangerous to purchase Xanax on the Internet or from vendors outside the United States. The complete flumazenil package insert should be consulted prior to use. Because of these risks, reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Acute withdrawal signs and symptoms associated with benzodiazepines have included abnormal involuntary movements, anxiety, blurred vision, depersonalization, depression, derealization, dizziness, fatigue, gastrointestinal adverse reactions (e.g., nausea, vomiting, diarrhea, weight loss, decreased appetite), headache, hyperacusis, hypertension, irritability, insomnia, memory impairment, muscle pain and stiffness, panic attacks, photophobia, restlessness, tachycardia, and tremor. Xanax is used to treat anxiety disorders and anxiety caused by depression. The risk of dependence is increased if you take higher doses or take this drug for a longer length of time. (5.2) Abrupt discontinuation or rapid dosage reduction of XANAX after Call your doctor right away if you have any of these signs of an allergic reaction to Xanax xr : -Hives a history of depression or suicidal thoughts or behavior; Even taking benzodiazepines as prescribed may put patients at risk for abuse and misuse of their medication. For the same reason, patients should be cautioned about the concomitant use of alcohol and other CNS depressant drugs during treatment with XANAX XR [see Drug Interactions (7.1)]. XANAX Tablets (alprazolam) are indicated for the management of anxiety disorder (a condition corresponding most closely to the APA Diagnostic and Statistical Manual [DSM-III-R] diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety. You can ask your pharmacist or healthcare provider for information about XANAX XR that is written for health professionals. Do not share your XANAX XR with other people. Thanks usamedzone.com Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Data from in vitro studies of alprazolam suggest a possible drug interaction of alprazolam with paroxetine. DOSAGE AND USE: See accompanying prescribing information. (, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. WebAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Patients with alcoholic liver disease exhibit a longer elimination half-life (19.7 hours), compared to healthy subjects (11.4 hours). The mean T1/2 of alprazolam was 16.3 hours (range: 9.0 to 26.9 hours) in healthy elderly subjects compared to 11.0 hours (range: 6.3 to 15.8 hours, n=16) in healthy adult subjects. Limit dosage and duration of XANAX XR during concomitant use with CNS depressants. In a controlled clinical trial in which 63 patients were randomized to XANAX and where withdrawal symptoms were specifically sought, the following were identified as symptoms of withdrawal: heightened sensory perception, impaired concentration, dysosmia, clouded sensorium, paresthesias, muscle cramps, muscle twitch, diarrhea, blurred vision, appetite decrease, and weight loss. Alprazolam exerts its effect for the treatment of panic disorder through binding to the benzodiazepine site of gamma-aminobutyric acid-A (GABAA) receptors in the brain and enhances GABA-mediated synaptic inhibition. Required fields are marked *. (, Limit dosages and durations to the minimum required. As a result, there may be difficulty in differentiating withdrawal symptoms from potential re-emergence or continuation of symptoms for which the benzodiazepine was being used. In order to properly inform the public, we have developed the following statement to be placed at the top of certain product pages: The products on this page have been transferred to VIATRIS SPECIALTY LLC. The following adverse reactions have occurred with benzodiazepine abuse and/or misuse: abdominal pain, amnesia, anorexia, anxiety, aggression, ataxia, blurred vision, confusion, depression, disinhibition, disorientation, dizziness, euphoria, impaired concentration and memory, indigestion, irritability, muscle pain, slurred speech, tremors, and vertigo. XANAX XR should be reduced to half of the recommended dosage when a patient is started on ritonavir and XANAX XR together, or when ritonavir is added to a patient treated with XANAX XR. Despite of low prices they are giving best quality FDA approved Drugs. Most of the interactions that have been documented with alprazolam are with drugs that modulate CYP3A4 activity. Alprazolam AUC and Cmax was reduced by 12% and 16%, respectively, in the presence of ritonavir. Monitor neonates exposed to benzodiazepines during pregnancy and labor for signs of sedation, respiratory depression, withdrawal, and feeding problems and manage accordingly [see Warnings and Precautions (5.4)]. WebThis product information is intended only for residents of the United States. Compared to morning dosing, alprazolam Cmax increased by 30% and the Tmax decreased by an hour following dosing at night. The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death [see Drug Abuse and Dependence (9.2)]. Carbamazepine: The oral clearance of alprazolam (given in a 0.8 mg single dose) was increased from 0.900.21 mL/min/kg to 2.130.54 mL/min/kg and the elimination T1/2 was shortened (from 17.14.9 to 7.71.7 hour) following administration of 300 mg per day carbamazepine for 10 days [see Drug Interactions (7.2)]. Observe newborns for signs of sedation and neonatal withdrawal syndrome and manage accordingly [see Use in Specific Populations (8.1)]. Its also available as a generic drug. Some patients may prove resistant to all discontinuation regimens. If your depression gets worse or you have suicidal thoughts, call your doctor right away. General supportive measures should be employed, along with immediate gastric lavage. The dosage of Xanax pills ranges from 0.25 milligrams to 3.5 milligrams. The mean T1/2 of alprazolam was 19.7 hours (range: 5.8 to 65.3 hours) in patients with alcoholic liver disease. Use of XANAX XR during the later stages of pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in the neonate. Adverse reactions are further categorized by body system and listed in order of decreasing frequency according to the following definitions: those occurring in at least l/l00 patients (frequent); those occurring in less than l/100 patients but at least l/1000 patients (infrequent); those occurring in fewer than l/1000 patients (rare). Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use. What is the most important information I should know about XANAX XR? Follow patients for signs and symptoms of respiratory depression and sedation, The use of benzodiazepines, including XANAX XR, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. The continued use of benzodiazepines, including XANAX XR, may lead to clinically significant physical dependence. However, following the expiration of its patent, other manufacturers are now free to make generic versions of Xanax. Ritonavir: Interactions involving HIV protease inhibitors (eg, ritonavir) and alprazolam are complex and time dependent. Advise patients, their families and caregivers to look for signs of suicidality or worsening depression, and to inform the patient's healthcare provider immediately [see Warnings and Precautions (5.6)]. Inform patients that the use of XANAX XR, even at recommended dosages, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose and death, especially when used in combination with other medications (e.g., opioid analgesics), alcohol, and/or illicit substances. But if you take several doses per day and miss a dose and its almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Each XANAX Tablet, for oral administration, contains 0.25, 0.5, 1 or 2 mg of alprazolam. I will recommend it. Also, dont stop taking this medication suddenly or decrease the dosage without talking to your doctor. The PfizerBioNTech COVID-19 vaccine (tozinameran), sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German company BioNTech. 9/11 Reckoning: Deconstructing the Deception, Wuhan Institute of Virology - Ralph S. Baric (Gain-of-function Researcher), Nazi Germany - Hitler's Residence (The Inalco House, Argentina), JFK - Howard Brennan (Assassination Witness), Wuhan Institute of Virology - Shi Zhengli (Lead Researcher), Nazi Germany - Reinhard Heydrich (Principal Architect of the Holocaust), The JFK Assassination (1963): The Truth Revealed, Pizzagate - Deep State Child Sex-Trafficking & Pedophilia, Pizzagate - Heavy Breathing (Amanda Kleinman). WebThe recommended starting oral dosage of XANAX for the acute treatment of patients with GAD is 0.25 mg to 0.5 mg administered three times daily. Before prescribing XANAX XR and throughout treatment, assess each patient's risk for abuse, misuse, and addiction (e.g., using a standardized screening tool). Closely monitor patients with impaired respiratory function. This means you may need to take it with other medications. Alprazolam produced no impairment of fertility in rats at doses up to 5 mg/kg per day, which is approximately 5 times the maximum recommended human dose of 10 mg per day based on mg/m2 body surface area. General information about the safe and effective use of XANAX XR. Xanax xr is used to treat anxiety disorders and panic attacks which manifest symptoms such as restlessness, flushing, shortness of breath, trembling, sweating, palpitations, and insomnia. It is not known if XANAX XR is safe and effective in the treatment of panic disorder for use longer than 8 weeks. Reproductive Health. XANAX XR U.S. Both types of white Xanax pills are manufactured by Pfizer. Short-term low doses of ritonavir (4 doses of 200 mg) increased mean AUC of alprazolam by about 2.5-fold, and did not significantly affect Cmax of alprazolam. Table 3 shows the incidence of discontinuation-emergent adverse reactions that occurred during short-term, placebo-controlled trials in 5% or more of patients treated with XANAX XR where the incidence in patients treated with XANAX XR was 2 times greater than the incidence in placebo-treated patients. Benzodiazepines cross the placenta and may produce respiratory depression and sedation in neonates. Set id: aa58fff3-c297-49be-838b-599c32ad9835, WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS. Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). Abrupt discontinuation or rapid dosage reduction of XANAX XR after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) [see Drug Abuse and Dependence (9.3)]. Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. Your healthcare provider can tell you more about the differences between physical dependence and drug addiction. These doses are 29 times and 4.8 times the maximum recommended human dose of 10 mg/day based on mg/m2 body surface area, respectively. It has been identified that alprazolam 2 mg tablets in bottles of 50 marketed as Xanax have been supplied without child-resistant caps. WebA white Xanax bar contains 2 mg in one whole pill, but can easily be split into four different segments. This drug belongs to a class of drugs called benzodiazepines. The dosage of Xanax pills ranges from 0.25 milligrams to 3.5 milligrams. The vaccine is given by intramuscular injection. Xanax alprazolam tablets, USP. Subsequently decrease the dosage more slowly [see Warnings and Precautions (5.3), Drug Abuse and Dependence (9.3)]. In these studies, patients were treated with XANAX XR in a dose range of 1 mg to 10 mg once per day. Limited data from published literature reports the presence of alprazolam in human breast milk. Angioedema has been reported, taking strong cytochrome P450 3A (CYP3A) inhibitors (e.g., ketoconazole, itraconazole), except ritonavir, Neonatal Sedation and Withdrawal Syndrome, Risks in Patients with Impaired Respiratory Function, breathing stops (which may lead to the heart stopping). 2 mg tablets) may be priced higher. Interactions involving ritonavir and alprazolam are complex and time dependent. Patients who are currently being treated with divided doses of XANAX may be switched to XANAX XR at the same total daily dose taken once daily. These lesions did not appear until after 11 months of treatment. XANAX XR is a prescription medicine used to treat panic disorder, with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. No evidence of carcinogenic potential was observed in rats or mice administered alprazolam for 2 years at doses up to 30 and 10 mg/kg/day, respectively. Drugs demonstrated to be CYP3A inhibitors on the basis of clinical studies involving alprazolam: nefazodone, fluvoxamine, and cimetidine [see Drug Interaction (7.1), Clinical Pharmacology (12.3)]. In patients with hepatic impairment, the recommended starting dosage of XANAX XR is 0.5 mg once daily. Xanax XR is used in the treatment of panic disorder and belongs to the drug class benzodiazepines . Do not take more XANAX XR than prescribed or take XANAX XR for longer than prescribed. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death. Begin with minimal doses of Xanax xr (0.25-0.5 mg / day), followed by a rise first in the evening and then in the daytime. Instances of irritability, hostility, and intrusive thoughts have been reported during discontinuation of alprazolam in patients with posttraumatic stress disorder. XANAX XR- alprazolamtablet, extended releasePharmacia & Upjohn Company LLC, XANAX XR is a benzodiazepine indicated for the treatment of panic disorder with or without agoraphobia, in adults. Physician Prescribing Information and Patient Information on this page may no longer be current. ( 1) DOSAGE AND ADMINISTRATION Recommended starting oral dosage is 0.5 mg to 1 mg once daily (preferably in the morning). Before prescribing XANAX XR and throughout treatment, assess each patient's risk for abuse, misuse, and addiction. Reduce XANAX XR dose when a patient is initiated with ritonavir and XANAX XR concomitantly, or when ritonavir is added to a regimen where XANAX XR is stabilized. The plasma circulation levels of the two active metabolites after both Xanax XR and Xanax are less than 10% and 4% of the parent, respectively. 4 yr. ago Damn, whats up with all the downvotes? The maximum recommended dosage is 4 mg daily (in divided doses). With anxiety, anxiety, the initial daily dose is 0.75-1.5 mg Xanax and can be increased to 3-4.5 mg / day.