technische universität braunschweig institut für mikrobiologie

Teaching Winter Semester 2020/2021; CS department TU Braunschweig Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. However, all current information coming from genomics, transcriptomics and proteomics (13) is also stored in our database as data warehouse (14) or dynamically accessible via web services using SOAP interfaces (15), a platform-independent data transfer protocol (see section ‘Database Techniques’). Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Beethovenstraße 55, 38106 Braunschweig, Germany Fax: +49‐531‐391‐2799===Search for more papers by this author Institut für Volkswirtschaftslehre, Technische Universität Braunschweig Collections in this community. Institutskolloquium am 26.01.206, Institut für Landschaftsbiogeochemie, Leibniz-Zentrum für Agrarlandschaftsforschung (ZALF) e. V. 2015 Anaerobic food chain as driver of biohydrogen and methane production from complex organic matter. Mit 'OK' verlassen Sie die Seiten der Universität Würzburg und werden zu Twitter weitergeleitet. The complexity of a systems biology approach requires the focus on a certain well investigated organism. Thank you for submitting a comment on this article. José V. Ramos. PGDv2 is the resource for the continually updated P.aeruginosa PAO1 genome annotation. Experimental conditions and methods are indicated along with the raw data. It also refers to genome annotation web sites of other Pseudomonas genome projects for the most up-to-date information. The S2 domain mediates viral fusion with the host … Principal institution: Department of Life Sciences (FLW), TU Braunschweig. Institut für Marketing, Technische Universität Braunschweig Collections in this community. If your group is not listed here, please send us an email : Register. A more dynamic and flexible tool for the visualization of multiple alignments is provided by Jalview (21), which is also accessible from SYSTOMONAS. Medizinische Hochschule Hannover. MEET US AT THE. PGD2, BioCyc, ENZYME also contributed to the functional annotation of enzymes. In the year 1862 the college is being renamed 'Polytechnische Schule' (poly-technical college) and academic training takes place in 8 technical and natural science subjects. The EC number source on the website is indicated accordingly. This organism is a versatile soil bacterium and an important opportunistic pathogen causing persistent infection in immunocompromised patients (12). Comparing a Pseudomonas protein of interest with other well-characterized proteins may deliver useful insights into the evolution, distribution and species specific function. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Our raw data analysed by GC/MS can be accessed via the query form ‘omics data’. Broad data integration is realized using SOAP interfaces for the well established databases BRENDA, KEGG and PRODORIC. The enzyme designation of proteins was determined in three steps. Table 1 lists parts of the corresponding database content. Braunschweiger Forscher ernten Kartoffeln für die Wissenschaft. All known metabolic reactions are depicted here for the ‘Urea cycle and metabolism of amino groups’ pathway. The metabolite name for every data point is shown as tooltip while moving the mouse over the point (e.g. Institut für Klinische Radiologie, Klinikum der Universität München, Munich, Germany München Vor 3 Tagen Gehören Sie zu den ersten 25 Bewerbern. This makes the Technische Universität the most established and traditional university in Germany. Technische Universität Braunschweig Institut für Füge- und Schweißtechnik. Data points are clickable and lead to the corresponding metabolite of the database (Figure 2). Street: Langer Kamp 8: Zip-Code: 38106: City: Braunschweig: Website: Long Description: The institute of joining and welding of the Technical University of Braunschweig has approximately 60 employees, 35 thereof being scientific staff. Several databases provide web services via SOAP, such as the major sequence databases (23–25). A metabolic network including all involved enzymes, metabolic reactions and metabolites of all pseudomonads is delivered by our own adapted tool, which is based on GraphViz (22) and creates clickable image maps (Figure 1). Sehen Sie, wen Institut für Klinische Radiologie, Klinikum der Universität München, Munich, Germany für diese Position eingestellt hat. Klaus Brehm Institut für Hygiene und Mikrobiologie. Dr. Chris Carrie, Ludwig-Maximilians-Universität München Plant inner mitochondrial membrane insertion pathways 13.01.2016 Prof. Ludger Beerhues, Institut für Pharmazeutische Biologie, Technische Universität Braunschweig Biotechnology of active plant polyketide derivatives 2015. 19, 79104 Freiburg, Germany. The web server is Apache 2.0 (Author Webpage). ; Institut für Organische und Biomolekulare Chemie, Georg‐ August‐Universität Göttingen Tammannstraße 2, 37077 Göttingen, Germany. We need your help to improve our website! E-mail address: h.waetzig@tu‐ Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Braunschweig, Germany. Most enzyme information was provided by KEGG. Search for more papers by this … If the user is interested in the prediction of transcription factor binding sites and the deduction of corresponding regulons the tool Virtual Footprint (4) can be employed. P. O. The novel betacoranavirus SARS-CoV-2 causes a form of severe pneumonia disease, termed COVID-19 (coronavirus disease 2019). * strain absent in KEGG (version 13th April 2006). Herzlich Willkommen auf der offiziellen Facebook-Seite der TU Clausthal! Region: Global Subject/journal group: All. Important Links . Institut für Angewandte Biowissenschaften. Institut für Mikrobiologie Startseite > Mitarbeiter > Prof. Horn ... manipulators of global warming. Herzlich mit vielen Willkommens-Mails wurde Professor Dan Schürch im Department Architektur Technische Universität Braunschweig empfangen. This makes the Technische Universität the most established and traditional university in Germany. Our database comprises information on eight different Pseudomonas species and strains, which genomes have been completely sequenced and functionally annotated. Search for other works by this author on: Institut für Biochemie, Universität zu Köln, Zülpicher Straße 47, D-50674 Köln, Germany, Fachbereich Informatik, Fachhochschule Wolfenbüttel, Institut für Bioverfahrenstechnik, Technische Universität Braunschweig, Gaußstraße 17, D-38106 Braunschweig, Germany, metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of, PathFinder: reconstruction and dynamic visualization of metabolic pathways, Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes, Expansion of the BioCyc collection of pathway/genome databases to 160 genomes, PRODORIC: prokaryotic database of gene regulation, BRENDA, the enzyme database: updates and major new developments, From genomics to chemical genomics: new developments in KEGG, The University of Minnesota Biocatalysis/Biodegradation Database: the first decade, BLAST: at the core of a powerful and diverse set of sequence analysis tools, EMBOSS: the European Molecular Biology Open Software Suite, MUSCLE: multiple sequence alignment with high accuracy and high throughput, An open graph visualization system and its applications to software engineering, DDBJ in preparation for overview of research activities behind data submissions, EMBL Nucleotide Sequence Database: developments in 2005, Atlas–a data warehouse for integrative bioinformatics, Systems biology markup language: level 2 and beyond. Ferit Küçükay Tagungsbeiträge . RWTH Aachen University | Technische Universität Berlin | Technische Universität Braunschweig | Technische Universität Darmstadt | Technische Universität Dresden | Leibniz Universität Hannover | Karlsruher Institut für Technologie | Technische Universität München | Universität Stuttgart Leibniz Universität Hannover . Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany Search for more papers by this author Jeroen S. Dickschat Our long term goal is the development of a dynamic model simulating the behaviour of P.aeruginosa during infection. Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. 649 were here. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Institut für Mikrobiologie. Data integration with SYSTOMONAS combines two different principle concepts, the data warehouse concept (14) and dynamic web services via SOAP. Gerhard Bringmann. Institut für Fahrzeugtechnik, Technische Universität Braunschweig Jan. 2019 –Heute 2 Jahre. Mean peak areas and standard deviations for the metabolites were calculated and plotted on a logarithmic scale using gnuplot (Author Webpage). 16.12.2015 Prof. Christiane Dahl, Mikrobiologie, Universität Bonn Additional information, such as kinetic data, operon structures or transcriptomics data are retrieved on-the-fly via web services from PRODORIC, BRENDA and KEGG (Table 2). All necessary information concerning this reaction is provided by mouse click. These pathways can be obtained from metabolic pathway entries. 031U110A/031U210A) and the Volkswagen Foundation. For this purpose, a major portion of the data of SYSTOMONAS, such as KEGG compounds, reactions or PRODORIC transcription factor—gene interactions is locally stored. Here we focus on data integration for the biotechnologically and medically relevant group of bacteria, the pseudomonads. None declared. Seit dem Beginn des Sommersemesters leitet der Schweizer Architekt das Institut für Entwerfen und Baugestaltung (IEB) ­– aus der Distanz, am 1. Leibniz Universität Hannover. Search for more papers by this author. Phone: +49 (0) 531 391-0 International business. Semi-quantitative scatter plot for the comparison of metabolic profiles measured for P.aeruginosa PAO1 grown under aerobic conditions. ENZYME (17) and BioCyc (5) provide further functional characterization of proteins. Reconstruction of metabolic networks in SYSTOMONAS was achieved via comparative genomics. 2Zentrum für Pharmaverfahrenstechnik (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany. for the data point ‘Lactate’) and linked back to the corresponding database entry. Rectangles depict metabolic reactions, ellipses represent metabolites whose names are abbreviated with an asterisk * when the length exceeds 10 letters. Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. Third, if the identity of the global alignment (stretcher) equals or exceeds 60%, all EC number connections to proteins were transferred to their orthologous protein partners. Bis 2020, Technologie Management, Technische Universität Braunschweig. The API (application programming interface) is constructed by the SOAP extension of PHP. Institut für Biophysikalische Chemie. Upon registration you will receive an e-mail for confirmation. University of California, Janin Heuer. The main data sources of SYSTOMONAS are stored and matched in an intermediate data container ‘metabold’, which supplies data to SYSTOMONAS (Figure 3). 2. Working Paper Series, Institut für Finanzwirtschaft, TU Braunschweig Technische Universität Braunschweig, Braunschweig, Germany The Institute for Information Systems at Technische Universität Braunschweig, Germany, focuses on research and teaching in the area of databases and information systems.. An abbreviation code for the species is provided with the visualization output (AO1 = P.aeruginosa PAO1, A14 = P.aeruginosa PA14, P = P.putida KT2440, Pf-5 = P.fluorescens F5, F01 = P.fluorescens PfO-1, ST = P.syringae pv tomato, SP = P.syringae pv phaseolicola, SS = P.syringae pv syringae). Our initial focus was on metabolomics. First, a restricted BLAST analysis (18) was performed on the protein sequences followed by a pairwise global alignment using the tool stretcher of the EMBOSS package (19). The web services via SOAP, which are used on the websites of SYSTOMONAS, are listed in Table 2. Institut für Energie- und Systemverfahrenstechnik, Technische Universität Braunschweig Professor Dr. Christoph Levin Evangelisch-Theologische Fakultät, Abteilung Altes Testament, Ludwig-Maximilians-Universität (LMU) München Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany . Harnessing lymphoma epigenetics to improve therapies (article not eligible for CME credit). Zur anonymisierten Webanalyse nutzt die TU Braunschweig die Software Matomo. Moreover, 11 exemplary protein spots from one proteome experiment were entered. Both types of nodes are clickable. Technische Universität Braunschweig, Helmholtz-Zentrum für Infektionsforschung. Niedersächsisches Forschungszentrum Fahrzeugtechnik, Institut für Fahrzeugtechnik, Technische Universität Braunschweig You'll find us here 01. Matthias Luttmann Masterand bei Institut für Raumfahrtsysteme, Technische Universität Braunschweig Braunschweig, Niedersachsen, Deutschland 33 Kontakte Search for more papers by this author. With 20,000 students and 3,700 employees, we are the largest technical university in Northern Germany. Institut für Fahrzeugtechnik TU Braunschweig Aufsätze in Zeitschriften Nr. We offer teaching, research and transfer with excellent facilities and a personal atmosphere at the same time. Phone: +49 (0) 531 391-0 Ovarian cancer risk score predicts chemo-response and outcome in epithelial ovarian carcinoma patients. (4)Institut für Mikrobiologie, Technische Universität Braunschweig; The user immediately recognizes enzymatic reactions unique to one Pseudomonas species. Second, homology analyses lead to putative orthologous protein pairs (see section ‘Comparative Genomics’). All newly detected EC numbers by metaSHARK are also indicated as ‘predicted’ in SYSTOMONAS. For this purpose, the engineering and science expertise of 9 institutes of the TU Braunschweig as well as Technische Universität Clausthal, Leibniz Universität Hannover, Fraunhofer Institute for Surface Engineering and Thin Films IST and Physikalisch-Technische Bundesanstalt (PTB) is bundled in this joined LabFactory. Social Media Facebook; Twitter; YouTube; Instagram; Kontakt. Your comment will be reviewed and published at the journal's discretion. We adapted this tool to SYSTOMONAS by limiting the analysis on Pseudomonas species. Chromatin structure restricts origin utilization when quiescent cells re-enter the cell cycle, NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis, The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration, Chemical Biology and Nucleic Acid Chemistry, Gene Regulation, Chromatin and Epigenetics, COMPARATIVE GENOMICS AND REGULATORY NETWORK PREDICTION, Receive exclusive offers and updates from Oxford Academic, M1CR0B1AL1Z3R—a user-friendly web server for the analysis of large-scale microbial genomics data, Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation, SUPFAM—a database of potential protein superfamily relationships derived by comparing sequence-based and structure-based families: implications for structural genomics and function annotation in genomes. In the year 1862 the college is being renamed 'Polytechnische Schule' (poly-technical college) and academic training takes place in 8 technical and natural science subjects. Contact. Intern BMW Manufacturing Co., LLC März 2020 – Sept. 2020 7 Monate. Economics Department Working Paper Series, TU Braunschweig The database structure of SYSTOMONAS is suitable for the simple storage of various types of experimental data. Currently, the data of SYSTOMONAS along with its visualization tools and web services can be accessed freely via a web-based user interface (Author Webpage). Angestellt, Werkstudentin am Institut für Marketing, Technische Universität Braunschweig. These services complement a specific record of the indicated SYSTOMONAS website form by transferring the appropriate information from the given external database. Herzlich willkommen auf der offiziellen Facebook-Seite der TU Braunschweig! However, there still exist only a few tools combining both networks such as the Pathway Tools Omics Viewer (5). There are various tools for metabolic network reconstruction [e.g. The focus of SYSTOMONAS is on pseudomonads and in particular Pseudomonas aeruginosa, an opportunistic human pathogen. TECHNISCHE UNIVERSITÄT MÜNCHEN Institut für Medizinische Mikrobiologie, Immunologie und Hygiene Control of immune responses towards self and non-self by Foxp3 + regulatory T cells Katharina Lahl Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt der Technischen Universität München zur Erlangung des akademischen … Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig. Combining knowledge from multiple disciplines and data resources will drive our understanding of cellular processes and lead to the prediction of the cellular behaviour in its entirety. Welcome to the Institute of Applied Biosciences (IAB) The Institute of Applied Biosciences was founded in 2005 and consists of seven different departments. Metabolites measured from samples of exponentially growing cells under aerobic conditions are plotted along the x-axis against metabolites from samples of resting cells along the y-axis. Foreign Languages. The homologous protein pairs can be obtained from the SYSTOMONAS protein table and visualized as multiple alignments, which are produced by MUSCLE [MUltiple Sequence Comparison by Log-Expectation (20)]. Deutsches Institut für Erwachsenenbildung, Leibniz-Zentrum für Lebenslanges Lernen Bonn IZA Institute of Labor Economics Forschungsinstitut zur Zukunft der Arbeit GmbH (IZA) Bonn University of Bonn Rheinische Friedrich-Wilhelms-Universität Bonn Braunschweig Technische Universtität Braunschweig Technische Universtität Braunschweig Institut für Technische Mikrobiologie. Both viruses use the human ACE2 receptor for cell entry, recognizing it with the Receptor Binding Domain (RBD) of the S1 subunit of the viral spike (S) protein. Technische Universität Braunschweig, Institut für Physikalische und Theoretische Chemie - NanoBioSciences, and Braunschweig Integrated Centre of Systems Biology (BRICS), and Laboratory for Emerging Nanometrology (LENA), Braunschweig University of Technology, Hans-Sommer-Straße 10, 38106 Braunschweig, Germany. The basis of our approach is SYSTOMONAS, a comprehensive database that includes data from all levels of analysis as microarray and proteomics data, metabolite measurements, sequence data, gene-regulatory networks and corresponding enzyme data. Information on transcription factor binding sites can be found for example in RegulonDB (6) or PRODORIC (7), while metabolic reactions or pathways need to be retrieved from other database, such as BRENDA (8), BioCyc (5), KEGG (9), PseudoCyc (10), and UM-BDD (11). Deutschland. In particular, the step of plasma membrane merger and the contributing proteins and physicochemical factors remain mostly unknown. Mareike Dressler. Different colours for rectangles specify distinct Pseudomonas species, which catalyse the corresponding reaction. Institut für Pharmazeutische Wissenschaften, Pharmazeutische Biologie und Biotechnologie, Albert-Ludwigs-Universität Freiburg, Stefan-Meier-Str. SYSTOMONAS architecture: combining the data warehouse concept and web services to provide a quick and dynamically updated data integration. Claudia Choi, Richard Münch, Stefan Leupold, Johannes Klein, Inga Siegel, Bernhard Thielen, Beatrice Benkert, Martin Kucklick, Max Schobert, Jens Barthelmes, Christian Ebeling, Isam Haddad, Maurice Scheer, Andreas Grote, Karsten Hiller, Boyke Bunk, Kerstin Schreiber, Ida Retter, Dietmar Schomburg, Dieter Jahn, SYSTOMONAS — an integrated database for systems biology analysis of Pseudomonas, Nucleic Acids Research, Volume 35, Issue suppl_1, 1 January 2007, Pages D533–D537, P. O. Research; Relationships; 1 August 2019 - 31 July 2020. Corresponding Author. Institut für Konstruktionstechnik - - - 1 Server: LSF19 Imprint and privacy Accessibility Statement QIS and LSF are products of eG Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig. All currently available transcriptome and proteome data are deposited in the database. Telefon (Sekretariat) +49 40 42878-32 08 | Fax +49 40 42878-23 15 | E-Mail First, the external databases KEGG (9), PGDv2 (16), ENZYME (17), BioCyc (5) provide EC numbers for the proteins. External web services implemented on the SYSTOMONAS (S.) websites via SOAP. To develop neutralizing anti-SARS-CoV-2 antibodies, antibody gene libraries from convalescent COVID-19 … Start. (Redirected from Technische Universität Braunschweig) The Technische Universität Braunschweig (unofficially University of Braunschweig – Institute of Technology), commonly referred to as TU Braunschweig, is the oldest Technische Universität [ de] (comparable to an institute of technology in the American system) in Germany. 2 Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Helmholtz Centre for Infection Research, Braunschweig, Germany Besides our own experimental metabolome, proteome and transcriptome data, various additional predictions of cellular processes, such as gene-regulatory networks were stored. Metabolites were analysed by GC/MS. Our core research fields are mobility, infections and therapeutics, metrology and the city of the future. The major advantage of SOAP is its up-to-dateness, since SOAP-transmitted information is corresponding to the most recent data of the consulted database. Traditionally, metabolic and gene-regulatory networks were analysed separately. We provide SBML (27) formatted files for downloading our metabolic and gene-regulatory networks along with a database copy at the SYSTOMONAS website. Graphical maps of corresponding gene regions can be retrieved via a hyperlink to the BRENDA Genome Explorer, a tool within the BRENDA package (8). the prediction of the regulation of certain genes by specific transcription factors. 10.06.2010 Rainer Renkawitz Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany. Technische Universität Braunschweig. Kolloquium 25.11.2015, Landesamt für … Besides the medically relevant P.aeruginosa the genera Pseudomonas contains various important plant pathogens and biotechnologically as well as ecologically interesting species. This work was funded by the German Bundesministerium für Bildung und Forschung (BMBF) for the National Genome Research Network (NGFN2-EP, grant no. Technische Universität Braunschweig Hans-Sommer-Straße 4 38106 Braunschweig Veröffentlichungen und Institutsberichte Prof. Dr.-Ing. Statistics of the metabolic network reconstruction for various Pseudomonas species in SYSTOMONAS. Search for more papers by this author. This poor connectivity between the two outlined approaches might be due to the fact that the required information is stored in different databases. Sprachen und interkulturelle Kommunikation, Graduiertenschulen und Graduiertenkollegs, Fakultät Architektur, Bauingenieurwesen und Umweltwissenschaften, Fakultät für Elektrotechnik, Informationstechnik, Physik, Fakultät für Geistes- und Erziehungswissenschaften, Braunschweiger Zentrum für Systembiologie (BRICS). 0313398A), BMBF for the Bioinformatics Competence Center Intergenomics (Grant No. : ++49 931-31-46168 Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. Es werden keine Bewerbungen mehr angenommen. Consequently, we constructed the database SYSTOMONAS, which provides the basis for a systems biology approach. (3)Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstrasse 7, Braunschweig 38106, Germany Helmholtz Centre for Infection Research, Braunschweig 38124, Germany. Currently, SYSTOMONAS contains 10 034 proteins identified as enzymes, 195 transcription factor–gene relations, 14 250 measuring points of three independent metabolome experiments. OK Abbrechen. Universität Regensburg, Institut für Biochemie, Genetik und Mikrobiologie … Further enzymes were annotated by comparative genomics (column ‘Predicted’), which were missing in the databases mentioned afore. Conflict of interest statement. Prof. Dr. rer. As an extra feature, the metabolomics data obtained for one specific growth condition can be plotted against another dataset using gnuplot (Author Webpage). Medizinische Hochschule Hannover. Axel Zeeck. 1 Türk-Alman Üniversitesi, Fen Fakültesi, Istanbul, Turkey Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Dear students and all interested parties, we are re-designing our website and want to include you in the process. 24.06.2010 Thomas Schirrmann, Technische Universität Braunschweig Generation of human antibodies and antibody fusion proteins for research, diagnostics and therapy 17.06.2010 Volker Wissemann; Institut für Botanik, Universität Gießen Host-parasite interaction in a case study of hybridogenic polyploids. If the metabolic profile during one experimental condition is similar to the condition compared, data points will arrange closely to the diagonal line.

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